La Liga MX Femenil presentó el calendario del Clausura 2022, el cual arrancará el 7 de enero y concluirá el 9 de mayo del año entrante.
El torneo constará de 17 jornadas, disputándose los cuartos de final del 5 al 9 de mayo. Las semifinales se llevarán a cabo del 12 al 16 de mayo, mientras que la gran final por el título se jugará tentativamente, la ida el 19 o 20 de mayo y la vuelta el 22 o 23 de mayo.
| JORNADA 1 | ||||||
|---|---|---|---|---|---|---|
| DÍA | HORA | LOCAL | VS | VISITANTE | ESTADIO | TRANSMISIÓN |
| 07/01/2022 | 20:00 | Mazatlán | vs | Cru Azul | Mazatlán | TVC |
| 08/01/2022 | 12:00 | Pumas | vs | León | O. Universitario | TUDN |
| 09/01/2022 | 12:00 | Puebla | vs | Toluca | Cuauhtémoc | TVC |
| 09/01/2022 | 20:00 | FC Juárez | vs | A. San Luis | A. Lastras | TUDN |
| 10/01/2022 | 19:00 | América | vs | Atlas | Azteca | TUDN |
| 10/01/2022 | 19:00 | Monterrey | vs | Querétaro | BBVA | FOX SPORTS |
| 10/01/2022 | 21:00 | Xolos Tijuana | vs | Santos | Caliente | NH |
| 10/01/2022 | 21:00 | Pachuca | vs | Chivas | Hidalgo | FOX SPORTS |
| 10/01/2022 | 17:00 | Necaxa | vs | Tigres | Victoria | TUDN |
| JORNADA 2 | ||||||
| DÍA | HORA | LOCAL | VS | VISITANTE | ESTADIO | TRANSMISIÓN |
| 14/01/2022 | 17:00 | Quéretaro | vs | Pachuca | O. Alameda | TVC |
| 15/01/2022 | 12:00 | Pumas | vs | América | O. Universitario | TUDN |
| 16/01/2022 | 17:00 | A.San Luis | vs | Cruz Azul | A. Lastras | ESPN |
| 16/01/2022 | 12:00 | Puebla | vs | Monterrey | Cuauhtémoc | TVC |
| 17/01/2022 | 12:00 | Atlas | vs | Mazatlán | Jalisco | TVC |
| 17/01/2022 | 17:00 | Toluca | vs | Xolos Tijuana | Nemesio Diez | TUDN |
| 17/01/2022 | 19:00 | León | vs | FC Juarez | Nou Camp | FOX SPORTS |
| 17/01/2022 | 21:00 | Santos | vs | Necaxa | TSM Corona | FOX SPORTS |
| 17/01/2022 | 19:00 | Tigres | vs | Chivas | Universitario | TUDN |
| JORNADA 3 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 24/01/2022 | 21:00 | Chivas | vs | Toluca | AKRON | FOX SPORTS / CHIVAS TV |
| 24/01/2022 | 19:00 | América | vs | Monterrey | Azteca | TUDN |
| 24/01/2022 | 21:00 | Xolos Tijuana | vs | A. San Luis | Caliente | NH |
| 24/01/2022 | 19:00 | Pachuca | vs | León | Hidalgo | FOX SPORTS |
| 22/01/2022 | 12:00 | Atlas | vs | Santos | Jalisco | TVC |
| 22/01/2022 | 12:00 | Cruz Azul | vs | Querétaro | La Noria | TUDN |
| 21/01/2022 | 19:00 | Mazatlán | vs | Puebla | Mazatlán | TVP |
| 24/01/2022 | 21:00 | FC Juárez | vs | Tigres | O. Benito Juárez | TUDN |
| 24/01/2022 | 17:00 | Necaxa | vs | Pumas | Victoria | TUDN |
| JORNADA 4 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 28/01/2022 | 17:00 | A.San Luis | vs | America | A. Lastras | ESPN |
| 27/01/2022 | 15:45 | Puebla | vs | Pachuca | Cuauhtémoc | TVC |
| 27/01/2022 | 10:00 | Monterrey | vs | Mazatlán | El Barrial | NH |
| 28/01/2022 | 17:00 | Quéretaro | vs | Pumas | O. Alameda | TVC |
| 27/01/2022 | 12:00 | Cruz Azul | vs | FC Juárez | La Noria | TUDN |
| 27/01/2022 | 19:00 | León | vs | Xolos Tijuana | Nou Camp | FOX SPORTS |
| 27/01/2022 | 21:00 | Santos | vs | Toluca | TSM Corona | FOX SPORTS |
| 28/01/2022 | 19:00 | Tigres | vs | Atlas | Universitario | TUDN |
| 28/01/2022 | 12:00 | Necaxa | vs | Chivas | Victoria | TUDN |
| JORNADA 5 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 31/01/2022 | 19:00 | Chivas | vs | Cruz Azul | AKRON | FOX SPORTS / CHIVAS TV |
| 31/01/2022 | 21:00 | Xolos Tijuana | vs | Tigres | Caliente | FOX SPORTS |
| 31/01/2022 | 15:45 | América | vs | Necaxa | C. 5 Coapa | TUDN |
| 31/01/2022 | 12:00 | Atlas | vs | Puebla | Jalisco | TVC |
| 31/01/2022 | 20:00 | Mazatlán | vs | A. San Luis | Mazatlán | TVP |
| 30/01/2022 | 10:00 | Toluca | vs | Pachuca | Nemesio Diez | TUDN |
| 31/01/2022 | 19:00 | León | vs | Querétaro | Nou Camp | NH |
| 30/01/2022 | 19:00 | FC Juárez | vs | Monterrey | O. Benito Juárez | TUDN |
| 31/01/2022 | 18:00 | Pumas | vs | Santos | O. Universitario | TUDN |
| JORNADA 6 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 06/02/2022 | 17:00 | A.San Luis | vs | Toluca | A. Lastras | ESPN |
| 07/02/2022 | 19:00 | Monterrey | vs | Pumas | BBVA | FOX SPORTS |
| 06/02/2022 | 12:00 | Puebla | vs | Xolos Tijuana | Cuauhtémoc | TVC |
| 04/02/2022 | 17:00 | Quéretaro | vs | Chivas | O. Alameda | TVC |
| 07/02/2022 | 17:00 | Pachuca | vs | FC Juárez | Hidalgo | FOX SPORTS |
| 05/02/2022 | 12:00 | Cruz Azul | vs | América | La Noria | TUDN |
| 04/02/2022 | 20:00 | Mazatlán | vs | Tigres | Mazatlán | TVP |
| 07/02/2022 | 19:00 | Santos | vs | León | TSM Corona | NH |
| 07/02/2022 | 17:00 | Necaxa | vs | Atlas | Victoria | TUDN |
| JORNADA 7 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 10/02/2022 | 21:00 | Xolos Tijuana | vs | Pachuca | Caliente | FOX SPORTS |
| 11/02/2022 | 17:00 | Quéretaro | vs | Mazatlán | O. Alameda | TVC |
| 12/02/2022 | 12:00 | Atlas | vs | A. San Luis | Jalisco | TUDN |
| 11/02/2022 | 17:00 | Toluca | vs | Monterrey | Nemesio Diez | TUDN |
| 10/02/2022 | 19:00 | León | vs | América | Nou Camp | FOX SPORTS |
| 13/02/2022 | 13:45 | FC Juárez | vs | Necaxa | O. Benito Juárez | TUDN |
| 12/02/2022 | 11:45 | Pumas | vs | Cruz Azul | O. Universitario | TVC |
| 10/02/2022 | 19:00 | Tigres | vs | Puebla | Universitario | TUDN |
| 13/02/2022 | 10:30 | Chivas | vs | Santos | Verde Valle | CHIVAS TV |
| JORNADA 8 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 27/02/2022 | 17:00 | A.San Luis | vs | Chivas | A. Lastras | ESPN |
| 28/02/2022 | 19:00 | América | vs | Mazatlán | Azteca | TUDN |
| 28/02/2022 | 21:00 | Monterrey | vs | Atlas | BBVA | FOX SPORTS |
| 27/02/2022 | 12:00 | Puebla | vs | Pumas | Cuauhtémoc | TVC |
| 28/02/2022 | 19:00 | Pachuca | vs | Tigres | Hidalgo | FOX SPORTS |
| 26/02/2022 | 12:00 | Cruz Azul | vs | Xolos Tijuana | La Noria | TUDN |
| 27/02/2022 | 17:00 | FC Juárez | vs | Toluca | O. Benito Juárez | TUDN |
| 28/02/2022 | 19:00 | Santos | vs | Querétaro | TSM Corona | NH |
| 28/02/2022 | 17:00 | Necaxa | vs | León | Victoria | TUDN |
| JORNADA 9 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 07/03/2022 | 19:00 | Chivas | vs | FC Juarez | AKRON | FOX SPORTS / CHIVAS TV |
| 06/03/2022 | 17:00 | A.San Luis | vs | Puebla | A. Lastras | ESPN |
| 05/03/2022 | 12:00 | Atlas | vs | Xolos Tijuana | Jalisco | TVC |
| 04/03/2022 | 20:00 | Mazatlán | vs | Necaxa | Mazatlán | TVP |
| 07/03/2022 | 17:00 | Toluca | vs | Cruz Azul | Nemesio Diez | TUDN |
| 07/03/2022 | 19:00 | León | vs | Monterrey | Nou Camp | NH |
| 05/03/2022 | 12:00 | Pumas | vs | Pachuca | O. Universitario | TUDN |
| 07/03/2022 | 21:00 | Santos | vs | América | TSM Corona | FOX SPORTS |
| 07/03/2022 | 19:00 | Tigres | vs | Querétaro | Universitario | TUDN |
| JORNADA 10 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 13/03/2022 | 21:00 | América | vs | Chivas | Azteca | TUDN |
| 14/03/2022 | 19:00 | Monterrey | vs | Necaxa | BBVA | FOX SPORTS |
| 14/03/2022 | 21:00 | Xolos Tijuana | vs | Pumas | Caliente | FOX SPORTS |
| 13/03/2022 | 12:00 | Puebla | vs | FC Juarez | Cuauhtémoc | TVC |
| 11/03/2022 | 17:00 | Quéretaro | vs | Atlas | O. Alameda | TVC |
| 12/03/2022 | 19:00 | Pachuca | vs | A. San Luis | Hidalgo | NH |
| 12/03/2022 | 12:00 | Cruz Azul | vs | Santos | La Noria | TUDN |
| 11/03/2022 | 20:00 | Mazatlán | vs | León | Mazatlán | TVP |
| 14/03/2022 | 17:00 | Toluca | vs | Tigres | Nemesio Diez | TUDN |
| JORNADA 11 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 18/03/2021 | 19:00 | Chivas | vs | Xolos Tijuana | AKRON | FOX SPORTS/ CHIVAS TV |
| 17/03/2022 | 20:00 | América | vs | Querétaro | Azteca | TUDN |
| 16/03/2022 | 10:00 | Monterrey | vs | A. San Luis | El Barrial | NH |
| 16/03/2022 | 19:00 | León | vs | Puebla | Nou Camp | FOX SPORTS |
| 17/03/2022 | 18:00 | FC Juárez | vs | Mazatlán | O. Benito Juárez | TUDN |
| 18/03/2022 | 17:00 | Pumas | vs | Atlas | O. Universitario | TUDN |
| 16/03/2022 | 19:00 | Santos | vs | Pachuca | TSM Corona | NH |
| 16/03/2022 | 19:00 | Tigres | vs | Cruz Azul | Universitario | TUDN |
| 16/03/2022 | 12:00 | Necaxa | vs | Toluca | Victoria | TUDN |
| JORNADA 12 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 21/03/2022 | 19:00 | Chivas | vs | Puebla | AKRON | FOX SPORTS/ CHIVAS TV |
| 20/03/2022 | 17:00 | A.San Luis | vs | Santos | A. Lastras | ESPN |
| 21/03/2022 | 21:00 | Xolos Tijuana | vs | Monterrey | Caliente | FOX SPORTS |
| 20/03/2022 | 17:00 | Quéretaro | vs | Necaxa | O. Alameda | TVC |
| 21/03/2022 | 12:00 | Atlas | vs | FC Juárez | Jalisco | TVC |
| 21/03/2022 | 12:00 | Cruz Azul | vs | Pachuca | La Noria | TUDN |
| 21/03/2022 | 20:00 | Mazatlán | vs | Pumas | Mazatlán | TVP |
| 21/03/2022 | 17:00 | Toluca | vs | Amérca | Nemesio Diez | TUDN |
| 21/03/2022 | 19:00 | Tigres | vs | Léon | Universitario | TUDN |
| JORNADA 13 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 26/03/2022 | 12:00 | Cruz Azul | vs | Atlas | La Noria | TUDN |
| 26/03/2022 | 19:00 / | FC Juárez | vs | Pumas | O. Benito Juárez | TUDN |
| 27/03/2022 | 17:00 | A.San Luis | vs | Tigres | A. Lastras | ESPN |
| 27/03/2022 | 12:00 | Puebla | vs | América | Cuauhtémoc | TVC |
| 27/03/2022 | 10:00 | Monterrey | vs | Santos | El Barrial | NH |
| 28/03/2022 | 21:00 | Xolos Tijuana | vs | Necaxa | Caliente | NH |
| 28/03/2022 | 19:00 | Pachuca | vs | Mazatlán | Hidalgo | FOX SPORTS |
| 28/03/2022 | 17:00 | Toluca | vs | Querétaro | Nemesio Diez | TUDN |
| 28/03/2022 | 21:00 | León | vs | Chivas | Nou Camp | FOX SPORTS |
| JORNADA 14 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 01/04/2022 | 16:00 | América | vs | FC Juarez | Azteca | TUDN |
| 31/03/2022 | 19:00 | Monterrey | vs | Pachuca | BBVA | FOX SPORTS |
| 01/04/2022 | 17:00 | Quéretaro | vs | Xolos Tijuana | O. Alameda | TVC |
| 02/04/2022 | 12:00 | Atlas | vs | Toluca | Jalisco | TVC |
| 01/04/2022 | 20:00 | Mazatlán | vs | Chivas | Mazatlán | TVP |
| 31/03/2022 | 19:00 | León | vs | Cruz Azul | Nou Camp | NH |
| 02/04/2022 | 12:00 | Pumas | vs | Tigres | O. Universitario | TUDN |
| 31/03/2022 | 21:00 | Santos | vs | Puebla | TSM Corona | FOX SPORTS |
| 31/03/2022 | 16:00 | Necaxa | vs | A. San Luis | Victoria | TUDN |
| JORNADA 15 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 17/04/2022 | 17:00 | A.San Luis | vs | Leon | A. Lastras | ESPN |
| 18/04/2022 | 21:00 | Xolos Tijuana | vs | América | Caliente | FOX SPORTS |
| 17/04/2022 | 12:00 | Puebla | vs | Necaxa | Cuauhtémoc | TVC |
| 18/04/2022 | 19:00 | Pachuca | vs | Atlas | Hidalgo | FOX SPORTS |
| 16/04/2022 | 12:00 | Cruz Azul | vs | Monterrey | La Noria | TUDN |
| 18/04/2022 | 17:00 | Toluca | vs | Mazatlán | Nemesio Diez | TUDN |
| 17/04/2022 | 19:00 | FC Juárez | vs | Querétaro | O. Benito Juárez | TUDN |
| 18/04/2022 | 19:00 | Tigres | vs | Santos | Universitario | TUDN |
| 17/04/2022 | 10:30 | Chivas | vs | Pumas | Verde Valle | CHIVAS TV |
| JORNADA 16 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 25/04/2022 | 19:00 | América | vs | Pachuca | Azteca | TUDN |
| 25/04/2022 | 21:00 | Monterrey | vs | Tigres | BBVA | FOX SPORTS |
| 22/04/2022 | 17:00 | Quéretaro | vs | Puebla | O. Alameda | TVC |
| 24/03/2022 | 12:00 | Atlas | vs | Chivas | Jalisco | TVC |
| 22/04/2022 | 20:00 | Mazatlán | vs | Xolos Tijuana | Mazatlán | TVP |
| 25/04/2022 | 19:00 | León | vs | Toluca | Nou Camp | NH |
| 24/03/2022 | 12:00 | Pumas | vs | A. San Luis | O. Universitario | TUDN |
| 25/04/2022 | 19:00 | Santos | vs | FC Juárez | TSM Corona | FOX SPORTS |
| 25/04/2022 | 17:00 | Necaxa | vs | Cruz Azul | Victoria | TUDN |
| JORNADA 17 | ||||||
| DÍA | HORA | LOCAL | vs | VISITANTE | ESTADIO | TRANSMISIÓN |
| 02/05/2022 | 19:00 | Chivas | vs | Monterrey | AKRON | FOX SPORTS/ CHIVAS TV |
| 02/05/2022 | 17:00 | A.San Luis | vs | Querétaro | A. Lastras | ESPN |
| 02/05/2022 | 21:00 | Xolos Tijuana | vs | Fc Juarez | Caliente | FOX SPORTS |
| 30/04/2022 | 19:00 | Pachuca | vs | Necaxa | Hidalgo | NH |
| 02/05/2022 | 12:00 | Atlas | vs | León | Jalisco | TVC |
| 30/04/2022 | 12:00 | Cruz Azul | vs | Puebla | La Noria | TUDN |
| 02/05/2022 | 17:00 | Toluca | vs | Pumas | Nemesio Diez | TUDN |
| 02/05/2022 | 19:00 | Santos | vs | Mazatlán | TSM Corona | NH |
| 01/05/2022 | 18:00 | Tigres | vs | América | Universitario | TUDN |
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